RESEARCH ARTICLE


The Chief Role of Frontal Operational Module of the Brain Default Mode Network in the Potential Recovery of Consciousness from the Vegetative State: A Preliminary Comparison of Three Case Reports



Alexander A. Fingelkurtsa, *, Andrew A. Fingelkurtsa, Sergio Bagnatob, c, Cristina Boccagni b, c, Giuseppe Galardib, c
a BM-Science - Brain and Mind Technologies Research Centre, Espoo, Finland
b Neurorehabilitation Unit, Rehabilitation Department, Fondazione Istituto “San Raffaele - G. Giglio”, Cefalù (PA), Italy
c Neurophysiology Unit, Rehabilitation Department, Fondazione Istituto “San Raffaele - G. Giglio”, Cefalù (PA), Italy


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© Fingelkurts et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the BM-Science – Brain and Mind Technologies Research Centre, P.O. Box 77, FI-02601, Espoo, Finland. Tel: +358 9 5414506, Fax: +358 9 5414507 E-mails: andrew.fingelkurts@bm-science.com; Url: www.bm-science.com/team/fingelkurts.html


Abstract

It has been argued that complex subjective sense of self is linked to the brain default-mode network (DMN). Recent discovery of heterogeneity between distinct subnets (or operational modules - OMs) of the DMN leads to a reconceptualization of its role for the experiential sense of self. Considering the recent proposition that the frontal DMN OM is responsible for the first-person perspective and the sense of agency, while the posterior DMN OMs are linked to the continuity of ‘I’ experience (including autobiographical memories) through embodiment and localization within bodily space, we have tested in this study the hypothesis that heterogeneity in the operational synchrony strength within the frontal DMN OM among patients who are in a vegetative state (VS) could inform about a stable self-consciousness recovery later in the course of disease (up to six years post-injury). Using EEG operational synchrony analysis we have demonstrated that among the three OMs of the DMN only the frontal OM showed important heterogeneity in VS patients as a function of later stable clinical outcome. We also found that the frontal DMN OM was characterized by the process of active uncoupling (stronger in persistent VS) of operations performed by the involved neuronal assemblies.

Keywords: Alpha rhythm, Default-mode network, DMN, Electroencephalogram, EEG, First-person perspective, Functional connectivity, Operational synchrony, Subjective sense of self, Unresponsive wakefulness syndrome, Vegetative state.