Aims and Scope
Divergences Between Resting State Networks and Meta-Analytic Maps Of Task-Evoked Brain ActivityMatías Palmucci and Enzo Tagliazucchi
The Open Neuroimaging Journal, 2022; 15: e187444002206270.
Electronic Publication Date: August 29, 2022
Analysis of Brain Structure and Neural Organization in Dystrophin-Deficient Model Mice with Magnetic Resonance Imaging at 7 TMitsuki Rikitake, Junichi Hata, Mayu Iida, Fumiko Seki, Rina Ito, Yuji Komaki, Chihoko Yamada, Daisuke Yoshimaru, Hirotaka James Okano and Takako Shirakawa
The Open Neuroimaging Journal, 2022; 15: e187444002202040.
Electronic Publication Date: March 09, 2022
Peak Activation Shifts in the Sensorimotor Cortex of Chronic Stroke Patients Following Robot-assisted Rehabilitation TherapyLoukas G. Astrakas, Shasha Li, Mark P. Ottensmeyer, Christian Pusatere, Michael A. Moskowitz, A. Aria Tzika
Ischemic stroke is the most common cause of complex chronic disability and the third leading cause of death worldwide. In recovering stroke patients, peak activation within the ipsilesional primary motor cortex (M1) during the performance of a simple motor task has been shown to exhibit an anterior shift in many studies and a posterior shift in other studies.
We investigated this discrepancy in chronic stroke patients who completed a robot-assisted rehabilitation therapy program.
Eight chronic stroke patients with an intact M1 and 13 Healthy Control (HC) volunteers underwent 300 functional magnetic resonance imaging (fMRI) scans while performing a grip task at different force levels with a robotic device. The patients were trained with the same robotic device over a 10-week intervention period and their progress was evaluated serially with the Fugl-Meyer and Modified Ashworth scales. Repeated measure analyses were used to assess group differences in locations of peak activity in the sensorimotor cortex (SM) and the relationship of such changes with scores on the Fugl-Meyer Upper Extremity (FM UE) scale.
Patients moving their stroke-affected hand had proportionally more peak activations in the primary motor area and fewer peak activations in the somatosensory cortex than the healthy controls (P=0.009). They also showed an anterior shift of peak activity on average of 5.3-mm (P<0.001). The shift correlated negatively with FM UE scores (P=0.002).
A stroke rehabilitation grip task with a robotic device was confirmed to be feasible during fMRI scanning and thus amenable to be used to assess plastic changes in neurological motor activity. Location of peak activity in the SM is a promising clinical neuroimaging index for the evaluation and monitoring of chronic stroke patients.
July 07, 2021
- November 25, 2020
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Developing the Standard of Care for Post-Concussion Treatment: Neuroimaging-Guided Rehabilitation of Neurovascular Coupling