REVIEW ARTICLE
High-Frequency Time-Resolved Scanning Acoustic Microscopy for Biomedical Applications
Pavlos Anastasiadis1, 2, *, Pavel V. Zinin3, 4
Article Information
Identifiers and Pagination:
Year: 2018Volume: 12
Issue: Suppl 1: M2
First Page: 69
Last Page: 85
Publisher ID: TONIJ-12-69
DOI: 10.2174/1874440001812010069
Article History:
Received Date: 31/2/2018Revision Received Date: 31/5/2018
Acceptance Date: 4/6/2018
Collection year: 31/12/2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
High-frequency focused ultrasound has emerged as a powerful modality for both biomedical imaging and elastography. It is gaining more attention due to its capability to outperform many other imaging modalities at a submicron resolution. Besides imaging, high-frequency ultrasound or acoustic biomicroscopy has been used in a wide range of applications to assess the elastic and mechanical properties at the tissue and single cell level. The interest in acoustic microscopy stems from the awareness of the relationship between biomechanical and the underlying biochemical processes in cells and the vast impact these interactions have on the onset and progression of disease. Furthermore, ultrasound biomicroscopy is characterized by its non-invasive and non-destructive approach. This, in turn, allows for spatiotemporal studies of dynamic processes without the employment of histochemistry that can compromise the integrity of the samples. Numerous techniques have been developed in the field of acoustic microscopy. This review paper discusses high-frequency ultrasound theory and applications for both imaging and elastography.