RESEARCH ARTICLE
Polyradiculopathies from Schwannomatosis
Yuxia Jia1, James A. Kraus2, Hasini Reddy2, Michael Groff 3, Eric T Wong*, 4
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
First Page: 9
Last Page: 13
Publisher ID: TONIJ-5-9
DOI: 10.2174/1874440001105010009
PMID: 21643503
PMCID: PMC3106375
Article History:
Received Date: 10/8/2010Revision Received Date: 18/10/2010
Acceptance Date: 25/10/2010
Electronic publication date: 18/1/2011
Collection year: 2011

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
We describe a case of schwannomatosis presenting as radicular pain and numbness in multiple radicular nerve distributions. There were multiple peripheral nerve tumors detected by magnetic resonance imaging (MRI) at the left vestibular nerve, cauda equina, right radial nerve, thoracic paraspinal nerve, and brachial plexi. Several resected tumors have features of schwannomas, including hypercellular Antoni A areas, hypocellular Antoni B areas, Verocay bodies, and hyalinized blood vessels. The specimens are also positive for immunohistochemical staining for INI1 with diffuse nuclear staining. The findings are consistent with sporadic form of schwannomatosis. This case highlights the importance of using MRI and INI1 immunohistochemistry to differentiate familial schwannomatosis, neurofibromatosis 2 (NF2)-associated schwannomatosis, and sporadic schwannomatosis.