RESEARCH ARTICLE


Imaging Stroke Evolution after Middle Cerebral Artery Occlusion in Non-human Primates



H.E D’Arceuil*, Alex J de Crespigny
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA


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© D’Arceuil and de Crespigny; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Athinoula A. Martinos Center for Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St., Rm 2301, Charlestown, MA 02129, USA; Tel: 617 726 8005; Fax: 617 726 7422; E-mail: helen@nmr.mgh.harvard.edu


Abstract

This article reviews imaging approaches applied to the study of stroke in nonhuman primates. We briefly survey the various surgical and minimally invasive experimental stroke models in nonhuman primates, followed by a summary of studies using computed tomography, positron emission tomography and magnetic resonance imaging and spectroscopy to monitor stroke from the hyperacute phase (within minutes of the onset of cerebral ischemia) to the chronic phase (1 month and beyond).

Keywords: Stroke, Primates, MRI, CT, PET, DSA, Diffusion MRI, Perfusion.