RESEARCH ARTICLE
Magnetic Resonance Characterization of Ischemic Tissue Metabolism
Jerry S Cheung1, Xiaoying Wang2, Phillip Zhe Sun*, 1
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
Issue: Suppl 1
First Page: 66
Last Page: 73
Publisher ID: TONIJ-5-66
DOI: 10.2174/1874440001105010066
PMID: 22216079
PMCID: PMC3245409
Article History:
Received Date: 8/9/2010Revision Received Date: 23/2/2011
Acceptance Date: 13/3/2011
Electronic publication date: 4/11/2011
Collection year: 2011

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Magnetic resonance imaging (MRI) and spectroscopy (MRS) are versatile diagnostic techniques capable of characterizing the complex stroke pathophysiology, and hold great promise for guiding stroke treatment. Particularly, tissue viability and salvageability are closely associated with its metabolic status. Upon ischemia, ischemic tissue metabolism is disrupted including altered metabolism of glucose and oxygen, elevated lactate production/accumulation, tissue acidification and eventually, adenosine triphosphate (ATP) depletion and energy failure. Whereas metabolism impairment during ischemic stroke is complex, it may be monitored non-invasively with magnetic resonance (MR)-based techniques. Our current article provides a concise overview of stroke pathology, conventional and emerging imaging and spectroscopy techniques, and data analysis tools for characterizing ischemic tissue damage.