Hippocampal Morphology in a Rat Model of Depression: The Effects of Physical Activity
Adam Sierakowiak *, 1, Anna Mattsson 2, Marta Gómez-Galán 2, Teresa Feminía 2, Lisette Graae 2, Sahar Nikkhou Aski 3, Peter Damberg 3, Mia Lindskog 2, Stefan Brené 1, Elin Åberg 4
Identifiers and Pagination:Year: 2015
First Page: 1
Last Page: 6
Publisher Id: TONIJ-9-1
Article History:Received Date: 29/9/2014
Revision Received Date: 1/12/2014
Acceptance Date: 11/12/2014
Electronic publication date: 30 /1/2015
Collection year: 2014
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Accumulating in vivo and ex vivo evidences show that humans suffering from depression have decreased hippocampal volume and altered spine density. Moreover, physical activity has an antidepressant effect in humans and in animal models, but to what extent physical activity can affect hippocampal volume and spine numbers in a model for depression is not known.
In this study we analyzed whether physical activity affects hippocampal volume and spine density by analyzing a rodent genetic model of depression, Flinders Sensitive Line Rats (FSL), with Magnetic Resonance Imaging (MRI) and ex vivo Golgi staining.
We found that physical activity in the form of voluntary wheel running during 5 weeks increased hippocampal volume. Moreover, runners also had larger numbers of thin spines in the dentate gyrus. Our findings support that voluntary wheel running, which is antidepressive in FSL rats, is associated with increased hippocampal volume and spine numbers.