RESEARCH ARTICLE


Attentional Networks in Adolescents with High-functioning Autism: An fMRI Investigation



Elizabeth C. Hames1, Ravi Rajmohan2, Dan Fang3, Ronald Anderson1, Mary Baker*, 1, David M. Richman4, Michael O’Boyle3
1 Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA
2 Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
3 College of Human Sciences, Texas Tech University, Lubbock, TX 79409, USA
4 College of Education, Texas Tech University, Lubbock, TX 79409, USA


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© Hames et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA; Tel: +18068340065; E-mail: mary.baker@ttu.edu


Abstract

Background:

Attentional deficits in Autism spectrum disorder (ASD) are often noted, but their specific nature remains unclear.

Objective:

The present study used the child Attentional Network Task (Child ANT) in combination with functional magnetic resonance imaging (fMRI) to determine if the consistently cited deficits of orienting attention are truly due to dysfunctions of orienting-based networks. We hypothesized that these observations are, in fact, a reflection of executive dysfunctions. As such, we expected that although ASD adolescents would perform worse on the orienting portion of the Child ANT, the strongest differences in activation between them and the neurotypical (NT) control group would be in areas classically associated with executive functioning (e.g., the frontal gyri and anterior cingulate cortex).

Method:

The brain activity of six high-functioning adolescents with ASD and six NT adolescents was recorded while these individuals performed the three subcomponents of the Child ANT.

Results:

ASDs were shown to be more accurate than NTs for the alerting, less accurate for the orienting, and similar in accuracy for the executive portions of the Child ANT. fMRI data showed increased bilateral frontal gyri recruitment, areas conventionally associated with executive control, during the orienting task for the ASD group.

Conclusion:

We submit that the increased activations represent neurocorrelates of signal fixation attributable to the subset of executive control responsible for sustained maintenance signals, not the main components of orienting. Therefore, excessive fixation in ASD adolescents is likely due to dysfunctions of executive control and not the orienting subcomponent of the attention network.

Keywords: Adolescents, ASD, Attention, Executive control, FMRI, High-functioning autism.