Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson’s Disease
K Reetz1, 2, H.R Siebner2, 4, C Gaser3, J Hagenah1, C Buechel2, 5, M Kasten6, D Petersen7, P.P Pramstaller8, C Klein1, F Binkofski*, 1, 2
Identifiers and Pagination:Year: 2008
First Page: 102
Last Page: 105
Publisher ID: TONIJ-2-102
Article History:Received Date: 20/1/2008
Revision Received Date: 15/8/2008
Acceptance Date: 20/8/2008
Electronic publication date: 27/9/2008
Collection year: 2008
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson’s disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.