Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson’s Disease

K Reetz1, 2, H.R Siebner2, 4, C Gaser3, J Hagenah1, C Buechel2, 5, M Kasten6, D Petersen7, P.P Pramstaller8, C Klein1, F Binkofski*, 1, 2
1 Department of Neurology, University of Luebeck, 23538 Luebeck, Germany
2 Imaging Center NeuroImage Nord, 20246 Hamburg, Germany
3 Department of Psychiatry, University of Jena, 07743 Jena, Germany
4 Department of Neurology, University of Kiel, 24105 Kiel, Germany
5 Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Germany 20246 Hamburg, Germany
6 Department of Psychiatry, University of Luebeck, 23538 Luebeck, Germany
7 Institute of Neuroradiology, University of Luebeck, Germany
8 Departments of Neurology, Central Hospital and Genetic Medicine, EURAC-Research, 38100 Bolzano-Bozen, Italy

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© Mintzopoulos et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Neurology, University of Luebeck, 23538 Luebeck, Germany; E-mail:


In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson’s disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

Keywords: Parkin mutation carriers, Parkinson’s disease, supplemetary motor area, voxel-based morphometry.