A Diffusion Tensor Imaging Study on the Auditory System and Tinnitus
Alessandro Crippaa, Cris P Lantingb, Pim van Dijkb, c, Jos B.T.M Roerdink*, a, c
Identifiers and Pagination:Year: 2010
First Page: 16
Last Page: 25
Publisher ID: TONIJ-4-16
Article History:Received Date: 13/5/2009
Revision Received Date: 1/6/2009
Acceptance Date: 13/10/2009
Electronic publication date: 30/6/2010
Collection year: 2010
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Tinnitus is an auditory percept in the absence of an external sound source. Mechanisms in the central nervous system are believed to be key in the pathophysiology of tinnitus. Diffusion tensor imaging (DTI) is an MR imaging technique that allows in vivo exploration of white matter tissue in the human brain. Using a probabilistic DTI approach, we determined the characteristics of fiber tracts from the inferior colliculus to the medial geniculate body up to the primary auditory cortex. We also investigated the connections between the auditory system and the amygdala, which may be involved in some forms of tinnitus. White matter tracts were characterized by three quantities: the mean fractional anisotropy, the weighted mean fractional anisotropy and the path strength. All these quantities are measures of the patency of white matter tracts. The most important finding is an increased patency of the white matter tracts between the auditory cortex and the amygdala in tinnitus patients as compared to healthy controls.