RESEARCH ARTICLE


Topographical Organization of Mu and Beta Band Activity Associated with Hand and Foot Movements in Patients with Perirolandic Lesions



Ronald B Willemse*, 1, Jan C de Munck2, Jeroen P.A Verbunt3, Dennis van ’t Ent2, 4, Peterjan Ris3, Johannes C Baayen1, Cornelis J Stam3, W. Peter Vandertop1
1 Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
2 Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
3 Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands
4 Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands


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© Willemse et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Neurosurgery, F2-010, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands; Tel: +31 (20) 444-3714; Fax: +31 (20) 444-3784; E-mail: r.willemse@vumc.nl


Abstract

To study the topographical organization of mu and beta band event-related desynchronization (ERD) associated with voluntary hand and foot movements, we used magnetoencephalographic (MEG) recordings from 19 patients with perirolandic lesions. Synthetic aperture magnetometry (SAM) was used to detect and localize changes in the mu (7 - 11 Hz) and beta (13 - 30 Hz) frequency bands associated with repetitive movements of the hand and foot and overlaid on individual coregistered magnetic resonance (MR) images. Hand movements showed homotopic and contralateral ERD at the sensorimotor (S/M) cortex in the majority of cases for mu and to a lesser extent for beta rhythms. Foot movements showed an increased heterotopic distribution with bilateral and ipsilateral ERD compared to hand movements. No systematic topographical segregation between mu and beta ERD could be observed. In patients with perirolandic lesions, the mu and beta band spatial characteristics associated with hand movements retain the expected functional-anatomical boundaries to a large extent. Foot movements have altered patterns of mu and beta band ERD, which may give more insight into the differential functional role of oscillatory activity in different voluntary movements.

Keywords: Magnetoencephalography - central nervous system disorders, intracranial cortical synchronization - beta rhythm.