Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects

Lirong Yan1, 2, Yan Zhuo1, Bo Wang1, Danny J.J Wang*, 2
1 Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
2 Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 577
Abstract HTML Views: 493
PDF Downloads: 167
Total Views/Downloads: 1237
Unique Statistics:

Full-Text HTML Views: 354
Abstract HTML Views: 281
PDF Downloads: 113
Total Views/Downloads: 748

© Yan et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the UCLA Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, 660 Charles E. Young Drive South, Los Angeles, CA 90095-7085, USA; Tel; 310-983-3667; 310-794-7406; E-mail:


Aging effects on blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) have been studied using task induced hemodynamic responses with controversial findings. The present study systematically investigated the normal aging effect in the visual cortex using 3 indices of low frequency fluctuations of resting state BOLD fMRI, i.e., amplitude of low frequency fluctuations (ALFF), regional homogeneity (ReHo) and functional connectivity (FC). These 3 resting state measurements were compared with task induced BOLD activation in the visual cortex of 2 groups of 10 young and 10 elderly subjects. Our results showed reduced functional connectivity and regional homogeneity of low frequency fluctuations of BOLD fMRI in aged subjects as compared to young subjects. While the mean magnitude of BOLD activation and the mean amplitude of low frequency fluctuations of BOLD fMRI did not vary between the 2 age groups, larger variances were observed in both measures in aged subjects. These data suggest that normal aging may be associated with “loss of coherence” of low frequency fluctuations of resting state BOLD fMRI in the visual cortex, and may affect task induced BOLD response through increased inter- and intra-subject variability.

Keywords: Blood-Oxygen-Level-Dependent (BOLD), Aging, Amplitude of Low Frequency Fluctuations (ALFF), Regional Homogeneity (ReHo), Functional Connectivity (FC).