# Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool

Daniel G Amen*, 1, Manuel Trujillo2, Andrew Newberg3, Kristen Willeumier1, Robert Tarzwell4, Joseph C Wu5, Barry Chaitin5
1 Amen Clinics, Inc.
2 New York University
3 Thomas Jefferson University
4 University of British Columbia
5 University of California, Irvine

#### Article Metrics

33
##### Total Statistics:

Full-Text HTML Views: 2262
Abstract HTML Views: 858
##### Unique Statistics:

Full-Text HTML Views: 1245
Abstract HTML Views: 409

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Amen Clinics, Inc. 4019 Westerly Place Suite 100, Newport Beach, CA 92660, USA; Tel: 949-266-3717; Fax: 949-266-3766; E-mail: docamen@amenclinic.com

## Abstract

Over the past 20 years brain Single Photon Emission Computed Tomography (SPECT) imaging has developed a substantial, evidence-based foundation and is now recommended by professional societies for numerous indications relevant to psychiatric practice. Unfortunately, SPECT in clinical practice is utilized by only a handful of clinicians. This article presents a rationale for a more widespread use of SPECT in clinical practice for complex cases, and includes seven clinical applications where it may help optimize patient care.

Keywords: Brain SPECT, evidence based, brain trauma, dementia, toxicity, complex cases.

## INTRODUCTION

“SPECT techniques provide a powerful window into the function of the brain and promise to become an important component of the routine clinical evaluation of patients with neurological and psychiatric diseases”[1].

This opening sentence to Holman and Devous’ 1992 article “Functional Brain SPECT: The Emergence of a Powerful Clinical Method,” highlighted the hope held for functional neuroimaging nearly two decades ago. A consistently growing body of research supports SPECT’s clinical utility. Fourteen years ago, Vasile wrote in the Harvard Review of Psychiatry [2], “The clinical utility of SPECT in neuropsychiatry is well established.” Nearly a decade ago, Camargo [3] wrote, “Brain SPECT … is rapidly becoming a clinical tool in many places. The importance of this technique should not be overlooked, particularly in cerebrovascular diseases, dementias, epilepsy, head injury, obsessive-compulsive disorder, Gilles de la Tourette's syndrome, schizophrenia, depression, panic disorder, and drug abuse.” Despite its evidence-base for multiple areas relevant to diagnosis and treatment few psychiatrists have adopted SPECT or other functional neuroimaging techniques in clinical practice.

This article lays out the evidence-based argument for the addition of SPECT for patients with complex presentations or who are treatment resistant. The article focuses on SPECT for three reasons. First, SPECT cameras are available in every major North American, European and Asian hospital making it the most widely available imaging modality available today. Second, SPECT has extensive research validating its usefulness for problems often faced by psychiatrists and is endorsed by scientific review bodies for many indications relevant to psychiatry. And, third, SPECT is among the least expensive neuroimaging tools and has had insurance reimbursement codes for greater than 20 years.

SPECT’s prolific use in peer-reviewed research supports that it is a well-established and reliable measure of brain function (regional cerebral blood flow—rCBF) [4]. Both the American College of Radiology [5] and the European Society of Nuclear Medicine (ESNM) [6] have published similar evidence-based guidelines for using SPECT to enhance patient care. Commonly accepted clinical indications for SPECT include:

• Evaluating patients for cerebrovascular disease.
• Evaluating patients with suspected dementia including early detection, differential diagnosis, and in the pre-dementia phase.
• Presurgical localization of epileptic foci.
• Evaluation of traumatic brain injury, especially in the absence of computed tomography (CT) and/or magnetic resonance imaging (MRI) findings.
• Evaluation of suspected inflammation to provide helpful information in progressive inflammatory disorders including viral encephalitis, vasculitis, and HIV-encephalopathy.
• Assessing brain death.

It is obvious to practicing psychiatrists that all of these indications, except perhaps brain death and the pre-surgical location of epileptic foci, are potentially valuable in clinical practice. Psychiatrists commonly evaluate and treat dementia and the consequences of brain trauma, cerebral vascular disease, inflammation and infections. Besides these common indications, the ESNM guidelines also state, “SPECT can be useful in other indications such as movement disorders and psychiatric diseases (e.g. for follow-up of depression).”

## SPECT BASICS

SPECT uses radioisotopes bound to neurospecific pharmaceuticals to evaluate rCBF and indirectly metabolic activity. Hexamethylpropyleneamine oximine (HMPAO) and ethylcysteinate dimer (ECD) are two commonly available FDA-approved radiopharmaceuticals; both provide regional cerebral blood flow (rCBF) images where the patient acts as his own control. A normal SPECT scan shows full, even, symmetrical perfusion [7], with the most intense perfusion in the cerebellum with HMPAO [8] and in the occipital lobes with ECD [9]. In reading SPECT images, experienced clinicians look for symmetry and areas of increased and decreased perfusion. See Figs. (1) and (2) for examples of healthy HMPAO scans. When evaluating SPECT, it is important to know the age of the patient. rCBF changes significantly over time. Children tend to have very active brains, older people less so [10].

 Fig. (1). Shows a healthy 3D surface rendering of SPECT information, looking at the top 45% of brain perfusion, anything below that level shows up as a hole or a dent. The holes do not mean no perfusion, they mean low perfusion, compared to a healthy dataset. Activity below the top forty-fifth percentile is 3 standard deviations below normal [10]. A healthy scan shows full, even, symmetrical perfusion.

 Fig. (2). Shows a healthy 3D active rendering of SPECT information, looking at areas of increased perfusion. Blue equals average perfusion, red equals the top 15% of perfusion and white is the top 8%. Activity above these levels is 2 and 3 standard deviations above normal outside the cerebellum(10). A healthy active scan with HMPAO shows increased perfusion in the cerebellum.

## SPECT HAS A SERIOUS IMAGE PROBLEM

SPECT has a serious ‘image’ problem related to many clinicians’ misunderstanding of its advantages and disadvantages. Five areas contribute to this problem:

1. There is a widely held idea that the clinical use of SPECT is restricted by limited resolution. Early SPECT practice utilized single-headed cameras that produced lower resolution images of about 12mm. However, sophisticated multi-headed gamma detectors with fan beam collimators have been available for the past two decades and can produce images with a resolution of 6mm. George reported that multi-head SPECT camera resolution is similar to PET at considerably less cost [11]. Multi-headed SPECT cameras cost between $100,000 for refurbished systems to$400,000 for new systems while PET/CT cameras cost between $1.5 to 3 million dollars [12]. This cost is then reflected in the price of the scans, with a SPECT scan averaging$1,100 versus a PET scan starting at $3,800. 2. Many nuclear medicine departments provide minuscule gray scale horizontal, coronal, and sagittal SPECT slices. The poor quality images are hard to read and understand. When clinicians cannot easily understand the images, they dismiss the technology as useless. Several current manufacturers provide software for three-dimensional image renderings that allow for more easily understandable images, such as those used in this article. Even though it is always necessary to evaluate the sliced images for appropriate detail, clinicians and patients need images that they can understand. 3. Functional neuroimaging training seldom combines radiologists and psychiatrists. Since psychiatry has yet to embrace this technology, many radiologists and nuclear medicine physicians have little to no training or experience in utilizing SPECT for neuropsychiatric indications. Even though the SPECT literature is replete with studies showing areas of increased perfusion in a number of psychiatric diagnoses and epilepsy most radiologists or nuclear physicians report only areas of decreased perfusion. More education and collaboration is needed among specialties. 4. Another common SPECT criticism is radiation exposure, especially in children. However, the average radiation exposure for one SPECT scan is 0.7rem (i.e., similar to a nuclear bone scan or head CT) and is considered safe. The Health Physics Society states, "There is no direct evidence of radiation ever causing any harm at the exposure levels encountered with diagnostic radiological examinations "[13]. The benefit-risk ratio of such radiation exposure needs to be evaluated against the considerable costs (monetary, and in terms of suffering and dysfunction) imposed by treatment resistant psychiatric disorders. 5. A final concern is why use SPECT over other brain imaging procedures that do not require ionizing radiation, namely perfusion/arterial spin labeling MRI and quantitative electroencephalography (QEEG). Perfusion/arterial spin labeling MRI is advantageous in that it doesn’t use ionizing radiation (it uses magnetically labeled endogenous blood water) and is minimally invasive; however, it is limited based on its low-signal-to-noise ratio and low temporal resolution. An alternative brain imaging modality, QEEG, does not require radiation and is low in cost ($600), however, it is limited to measuring brain wave activity at the scalp, and gives limited information regarding subcortical structures.

## CLINICAL APPLICATIONS OF BRAIN SPECT IMAGING

Several important patterns have emerged from SPECT research that has direct application to day-to-day clinical practice. Here are 7 examples:

### 1. Overall Decreased Perfusion

This pattern is often associated with toxicity, illness or insult to the brain. It is frequently seen in drug and alcohol abuse, abuse of prescription medications such as benzodiazepines, environmental toxins, such as carbon monoxide poisoning, infectious disease, such as meningitis, anoxic states, significant hypothyroidism, anemia, chemotherapy and severe dehydration. Seeing this pattern does not give the etiology, but alerts clinicians to search for causes which will allow them to understand it.

Here is an example: A couple came for evaluation after their marital therapist told them she thought they should get divorced. They’d been treated for three years and spent nearly \$20,000 in care. The husband’s diagnosis was mixed personality disorder with narcissistic and antisocial features. The couple’s family physician recommended another opinion that included SPECT scans. The husband’s scan showed overall decreased perfusion (Fig. 3). The husband reported that he didn’t drink alcohol and had never used drugs, which his wife confirmed. The scan results caused his physician to think through a completely different differential diagnosis beyond personality disorder. It turned out that the husband worked in a furniture factory, finishing cabinets. The inhalants found in finishing products may compromise brain functioning and show a toxic pattern on scans [14]. Marital therapy is destined to fail until the husband is removed from the toxic environment. This information significantly changed the treatment plan and was instrumental in helping the couple’s marriage.

 Fig. (3). Toxic Surface Scan notice the “Swiss cheese, shriveled appearance, indicating areas of decreased perfusion.

### 2. Traumatic Brain Injury (TBI) Patterns

TBI is a major public health concern. TBI survivors commonly face a range of psychiatric disorders, affecting functional status, cognition, and mood [15]. Of course, not everyone with a significant brain injury has lasting symptoms. Those who do, however, present daunting problems of differential diagnosis. But how does a psychiatrist know about individual patients and brain injury unless they look? Relying on clinical history alone is inadequate. Even upon extensive questioning, many patients forget that they have sustained a significant brain injury. The following case demonstrates this frustrating problem:

A 26 year old male patient with severe impulsivity and depression in a drug treatment program was asked 10 times, with extensive examples, whether or not he had a brain injury. He said no each time. His SPECT scan (Fig. 4), however, showed evidence of substantial hypoperfusion, consistent with trauma in the left frontal-temporal lobe region. When asked again, he then remembered a motorcycle accident where he broke his left jaw, near the site of his SPECT deficit.

 Fig. (4). Trauma. Asymmetrical decreased perfusion left frontal temporal lobe.

SPECT can help identify if trauma is present and which brain system or systems are affected. Common findings in trauma on SPECT include:

• focal decreased near sight of injury and/or opposite side (contra coup)
• asymmetrical hypoperfusion in the prefrontal, temporal, parietal or occipital lobes
• flattening of the prefrontal pole
• decreased anterior temporal poles
• decreased contralateral cerebellar perfusion.

SPECT aids in understanding TBI patients’ symptomatology and assists clinicians in developing targeted treatment strategies [16, 17]. For example, decreased prefrontal cortex perfusion is often associated with executive dysfunction and may be helped with psychostimulants or other strategies to enhance frontal lobe function; whereas decreased temporal lobe perfusion is often associated with irritability and mood instability and may be helped with anticonvulsant medication. Literature indicates that SPECT helps evaluate perfusion abnormalities not only in blunt brain trauma, but also in cases of post-concussive syndrome and whiplash [18]. Brain injured patients with normal EEG, CT, and/or MRI scans often complain of headaches, memory loss, concentration difficulties, dizziness, perceptual sensitivities, and emotional lability. Such patients may be labeled as malingering, when there are significant and demonstrable functional abnormalities present. Researchers investigating the differences between functional and structural imaging techniques have found SPECT to be more sensitive for patients with varying degrees of head trauma [19].

Researchers have also compared the differences between functional and structural imaging in relation to clinical outcome and prognosis. Jacobs et al. [16] used SPECT to prospectively evaluate 67 mild-to-moderate brain injured patients. Each patient had a clinical evaluation and SPECT scan within four weeks of the initial injury and three months after the first scan. Of the 33 patients who showed no significant abnormalities on their initial scan, 97% resolved their clinical symptoms within three months. By contrast, in the 34 patients with abnormal initial SPECT scans, 59% continued to experience significant clinical symptoms three months later. The positive predictive value of an abnormal initial scan was only 20/34 (59%), but if the second scan 12 months later was also abnormal the sensitivity for the repeat SPECT was 19/20 (95%). These authors suggest that negative initial SPECT studies are a reliable predictor of a favorable clinical outcome.

SPECT assists in the diagnosis, prognosis, and treatment of TBI patients. SPECT may also help uncover brain trauma in clinically confusing or complex cases because patients often fail to report or forget about significant brain injuries, perhaps due to peri-traumatic amnesia. A limitation for SPECT’s use in brain trauma is that typically no prior SPECT study is available for comparison. Therefore, it is often not possible to date the trauma with neuroimaging. Remote trauma from childhood often presents neuroimaging findings similar to those seen in more recent trauma.

### 3. Evaluating Cognitive Decline

To date, autopsy reports have been the “gold standard for an Alzheimer’s Disease (AD) diagnosis.” However, research suggests that SPECT, when used in conjunction with clinical history and other diagnostic tests, is helpful when evaluating patients who are experiencing cognitive decline [20] and should be used to help differentiate AD, vascular dementia (VaD), frontal lobe dementia (FLD), suspected Lewy Body Dementia (LBD), normal pressure hydrocephalus (NPH) and pseudodementia (PSD) if the diagnosis is in doubt [21]. The functional brain imaging patterns associated with AD include decreases in the posterior cingulate gyrus, parietal and medial temporal lobes; FLD include frontal and temporal lobe deficits; VaD, a vascular pattern of decreased activity in multiple areas; LBD often shows decreased occipital lobe perfusion; NPH is associated with enlarged ventricles out of proportion to cortical atrophy; and PSD often shows an absence of dementia patterns with increased limbic activity [22]. This differential is critical because the use of high potency antipsychotics in patients with LBD, which often affects the occipital lobes on SPECT [23], can cause severe and sometimes irreversible deterioration. Patients diagnosed with different dementia disorders often present with similar symptomatology (e.g., social withdrawal and behavioral disinhibition). Because treatments for these disorders vary, differential diagnosis is critical, particularly since some dementia patients will have a reversible cause, such as depression or normal pressure hydrocephalus, or a cause they may be significantly stabilized with aggressive intervention, such as VaD.

Here is a case example: L, a 73 year old male, suffered with persistent memory problems. His neurologist, without the benefit of imaging, diagnosed him with AD. Memantine and donezepil had no effect. Two years later, his family brought him for further evaluation. His SPECT scan showed significantly enlarged ventricles, without concomitant cortical atrophy (Fig. 5). His scan did not show the typical low posterior cingulate and bilateral temporal-parietal hypoperfusion, consistent with AD. Given the pattern, and subsequent MRI, he was diagnosed with normal pressure hydrocephalus (NPH). After a shunt his memory markedly improved.

 Fig. (5). Transaxial Slices. Slices 12 and 13 show inverted lobster pattern associated with ventricular enlargement.

Some would argue that an MRI would be a more appropriate study in evaluating NPH, which the authors agree. Yet, functional imaging studies like SPECT provide a wealth of other data, such as giving information on areas of increased and decreased perfusion, in addition to enlarged ventricles, making it is useful screening tool. For example, Bonte et al. [24] performed SPECT studies in patients with possible dementia and compared them to images of an elderly healthy control group. Histopathologic correlation was available in 54 patients (with autopsy in 51, with biopsy in three). The results of the study showed SPECT diagnoses were true-positive in 37, true-negative in eight, false-positive in three, and false-negative in six patients. Sensitivity was 86%; specificity, 73% and the positive predictive value was 92%, with an accuracy of 83%. The authors concluded that SPECT assists in the early and late diagnoses of AD and in the differential-diagnosis of the dementias when there is a complicated or confusing clinical picture.

### 4. Negative Emotionality and Hyperfrontality

Hyperfrontality, or increased perfusion in the prefrontal cortex and anterior cingulate gyrus, is associated with a number of different psychiatric illnesses that have a common theme of cognitive inflexibility or getting stuck on negative thoughts or negative behaviors, such as in obsessive compulsive disorder (OCD) [25, 26], autism, posttraumatic stress disorder, and certain types of anxiety and mood disorders [27, 28]. This pattern is often seen in patients who struggle with being rigid, inflexible and oppositional [29], and crosses several different diagnostic groups.

When SPECT scans detect the hyperfrontality pattern, it opens new avenues for intervention since this finding has been associated with predicting a positive treatment response to serotonergic medication in depression [30-34] and OCD [35, 36], predicting a positive response to sleep deprivation [37, 38] and repetitive transcranial magnetic stimulation[39] for depression, predicting treatment response to a cingulotomy in OCD [40], and help in distinguishing OCD from ADHD [41].

Hyperfrontality will never give a classic DSM diagnosis per se, but rather it provides new directions for treatment by providing a picture of the brain physiology underlying the clinical presentation.

Here is a clinical example. V, a 17 year old male, had severe temporal lobe epilepsy. He also had aggression that was non-responsive to behavioral interventions. His SPECT scan showed severely decreased perfusion in his left temporal lobe (Fig. 6) consistent with epilepsy, and he showed severely increased perfusion in the anterior cingulate gyrus and lateral frontal lobes (Fig. 7), a pattern consistent with OCD. Even though V did not have clear OCD symptoms, he was rigid, inflexible and easily upset when something did not go his way. With the addition of sertraline, an antidepressant that tends to lower rCBF in this brain region [31], his behavior significantly improved. Managing V without the benefit of scans handicapped the doctor, patient and family.

 Fig. (6). Outside Surface Scan severe left temporal lobe hypoperfusion (arrow).

 Fig. (7). Active scan severe hyperfrontality (arrow).

### 5. Behavioral Problems and Hypofrontality

Hypofrontality, decreased perfusion or activity in the prefrontal cortex, is another important SPECT finding that is often helpful in understanding and targeting treatment in individual patients. Hypofrontality is associated with a negative response to serotonergic medication in depression [30] and clozapine in schizophrenia [42] as well as with predicting relapse in alcoholics [43], improved response to acetylcholine-esterase inhibitors for memory and behavior in AD [44, 45], predicting a poor response to ketamine in fibromyalgia patients [46] and improved response to stimulants in patients with ADHD symptoms during a concentration challenge [47]. Hypofrontality is also associated with antisocial symptoms, impulsive behaviors, and murder [48, 49] as well as with completed suicide, which is often an impulsive act [50]. When hypofrontality is present in depressed patients, it is important to be vigilant in their care, as well as involve family support, as they may be less likely to respond to typical antidepressant medications and they may not have the cognitive resources to follow through with recommendations.

Given its broad range of involvement in different types of psychiatric illness hypofrontality, like other findings, will not give a specific psychiatric diagnosis, but it allows the clinician to know the underlying pathophysiology of the patient’s presenting problem and can help explain issues with cognitive impairment or behavioral problems.

### 6. Mood Instability, Memory Problems and Temporal Lobe Abnormalities

Evaluating temporal lobe function is important in psychiatric medicine, especially as it relates to the evaluation of patients with memory problems, mood instability, aggression, and receptive and expressive language [51]. As described above, the temporal lobes are commonly affected in brain injury. Their function however cannot be evaluated simply by clinical phenomenology. SPECT offers a reliable tool to evaluate temporal lobe function. According to Devous et al. ”Both SPECT and PET have localizing power approaching that of combined scalp and depth EEG.”[52] Patients with epilepsy have high psychiatric comorbidity [53], and psychiatrists increasingly rely on the use of anticonvulsants as ‘mood stabilizers,’ which are shown to stabilize or calm overall brain activity and perfusion, especially in the temporal lobes [54, 55].

Temporal lobe epilepsy (TLE) is one of the most frequently encountered chronic epileptic disorders and is associated with numerous psychiatric symptoms, such as depressed mood, anergia, irritability, euphoric mood, atypical pain, insomnia, fear, and anxiety [56]. The medial temporal lobes are frequently involved in TLE and they are difficult to evaluate with routine EEG studies and therefore may be missed. SPECT findings in epilepsy most often reveal focal decreased perfusion in the interictal phase and focal increased perfusion in the seizure’s ictal phase. SPECT adds to the clinical evaluation of temporal lobe function by identifying area(s) of abnormality and showing deficits not seen by EEG.

Based on the authors’ clinical experience, when abnormalities in the temporal lobes are seen (either low or high perfusion) and mood instability or temper problems are present, anticonvulsants provide a rational treatment option [57]. If there are memory or learning issues (and low temporal lobe perfusion), acetylcholine-esterase inhibitors may be helpful [58], always taking into consideration the clinical picture.

Here is an example: C, age 12, was hospitalized for attacking another child at school. This was his third psychiatric hospitalization. C had been diagnosed with ADHD at age 6, but stimulants caused him to hallucinate. At age 9 he was hospitalized for an aggressive episode, diagnosed with a mood disorder and placed on an antidepressant without benefit. By age 12 he had been in psychotherapy for 3 years, also without benefit. Given his resistant illness, and the tens of thousands of dollars spent on his care, a brain SPECT study was ordered which showed severe left temporal lobe hypoperfusion (Fig. 8). Unilateral temporal lobe hypoperfusion is often seen with epileptic phenomena [52]. On an anticonvulsant C’s behavior normalized and he has maintained his progress for over 10 years.

 Fig. (8). C’s Brain SPECT Study severe hypoperfusion left temporal lobe (arrow).

### 7. Subtyping Dimensional Behavior to Predict Treatment Response

SPECT’s use in clinical practice dovetails closely with the spirit of NIMH’s RDoC initiative which looks to develop new ways of classifying psychopathology based on observable behavior and neurobiological measures [59]. In order to construct such a system, it is necessary to obtain accurate measures of the functioning of the brain systems which support various normal and abnormal emotions, undergird critical functions such as attention and memory, and modulate functions such as aggression. SPECT scans have the possibility of facilitating the subtyping of mental illnesses, such as depression, ADHD, obsessive-compulsive disorder, and aggression based on brain system pathophysiology.

## SUBTYPING AGGRESSION

The role of brain function in aggression is one of NIMH’s five major domains of interest and an area where SPECT imaging may provide immediate clinical help. From the authors’ work with 75 murderers, and hundreds of patients who have exhibited serious aggressive behavior ranging from assault, robbery, rape, kidnapping, arson, bombings, to road rage, and stalking, we have seen that aggressive behavior is not defined by one single brain finding, but rather clusters in at least three different patterns. The first is impulsive aggression, associated with hypofrontality, a finding reported in antisocial personality disorder [60, 61]. Patients with a compromised prefrontal cortex are frequently unable to regulate aggressive impulses and are at higher risk for exhibiting violent activity than other patients. The second cluster we have labeled ‘compulsive aggression,’ often associated with hyperfrontality, where people act out because they cannot get negative thoughts out of their minds, or because they are extremely rigid and inflexible. The third cluster of aggressive patients we’ve seen have SPECT findings of temporal lobe abnormalities. Soderstrom et al. [62] retrospectively evaluated violent subjects’ SPECT and MRI scans and compared them to the SPECT results obtained from a group of volunteers who had no history of a neurological or psychiatric disorder, head trauma, or metabolic disease. Sixteen of the 21 impulsively violent subjects showed some hypoperfusion in the temporal and/or frontal lobes upon visual inspection. By contrast, MRI failed to show any corresponding structural damage or abnormalities in this sample of violent offenders. Another study of recidivistic violent offenders [63] revealed that the largest functional deficits in their violent patients were found in the temporal lobe. These abnormalities were similarly found in subjects whose structural CT scans were normal. Knowing a violent patient’s underlying brain pattern may be helpful to getting them the right help. In the authors’ experience we have often seen multiple patterns associated with violence, such as low prefrontal cortex and temporal lobe perfusion.

Here are two examples of 15 year old males, multiple murderers, who had significantly different SPECT patterns, which would lead to different clinical management decisions.

KK was diagnosed with ADHD, dyslexia and depression. He had been evaluated by two psychiatrists and placed on a psychostimulant and SSRI without benefit. He was arrested after bringing weapons to his high school. After he was released from jail he murdered his mother and father and then went back to his high school the next morning and shot 24 people, killing two more. As part of his pre-trial evaluation, a SPECT scan was performed and showed severe overall decreased perfusion, especially in the area of the left medial temporal lobe and inferior orbital prefrontal cortex. The scan was consistent with prior toxic exposure, anoxia or infection. The SPECT scan and history raise the possibility that an anticonvulsant (given the severe decreased left temporal lobe perfusion) followed by a psychostimulant (to enhance his low prefrontal cortex perfusion) was worth considering to help modulate his aggressive impulses.

PP had been diagnosed with ADHD and dyslexia. In a rage he murdered his mother and eight year old sister. PP’s SPECT scan showed significant hyperfrontality, especially in the anterior cingulate gyrus. As noted above, this presentation is more likely to respond to an SSRI.

Here is the same symptom presentation, multiple murder, but very different brain patterns. The differences in the scan patterns give suggestions for different treatment regimens.

## SUBTYPING DEPRESSION

Anxiety and depressive disorders are two of the most common psychiatric problems worldwide and subtyping these disorders using brain system pathology is an important step in improving treatment outcomes [64]. Functional imaging, including SPECT, helps to elucidate this process in individual patients. As noted above, hyperfrontality is associated with a positive response to SSRIs in depressed and anxious patients, while hypofrontality is associated with a negative response, and has been reported in completed suicides. Little et al., on the other hand, found that lower prefrontal activity prior to treatment was associated with a positive response to buproprion and venlafaxine [65]. These medications involve enhancing dopamine and norepinephrine, which in the authors’experience, tend to enhance prefrontal cortex activity, while SSRIs tend to be calming [31]. Up to 50 or 60% of patients with chronic epilepsy have various mood disorders including depression and anxiety [66, 67]. Using SPECT gives the clinician a more rational reason to use anticonvulsants when focal areas of increased or decreased perfusion are seen, especially in the temporal regions. Likewise, if overall decreased perfusion is present, it alerts the clinician to look for toxic or metabolic causes of the problem, or if a brain trauma pattern is seen, commonly associated with anxiety and mood disorders, this can be investigated further as well.

## CONCLUSION

There are a number of important areas where SPECT has the potential to provide relevant information to help personalize treatment to patients’ specific brain system pathophysiology rather than rely solely on general diagnostic and/or therapeutic categories. In this paper we described 7 such areas. Furthermore, in the authors’ experience, another immediate benefit of using brain SPECT imaging is that the patient’s and family’s guilt, shame and stigma are significantly reduced as they see their illness as medical rather than moral with concurrent improvements in treatment compliance. In the authors’ opinion, brain SPECT or any other neuroimaging modality should always occur in conjunction with clinical assessment since it is not the isolated diagnostic accuracy that has greatest importance but rather the value added to routine clinical assessment.

Over the last quarter century, there has been much discussion of the “Future of Psychiatry” [68] as we move into a more biologically based paradigm. How would we maintain our subjective patient focus within this new framework? Reynolds, Lewis, Detre, Schatzberg and Kupfer [69] have weighed in on this work in progress. One thing that is becoming very clear is that our resident trainees may require more exposure to translational neuroscience during their early years of residency and neuroimaging needs to be an important component of this curriculum. A recent report demonstrated the integration of a neuroimaging module within a residency program had wide approval by residents. Other programs have experimented with variations but within the neurology rotation of the PGY-1 year. The Psychiatry RRC of the ACGME will need to take this on in earnest for the development of the field.

This is an exciting time in the history of psychiatry, as the field will likely significantly change over the next 30 years to incorporate functional neuroimaging in clinical practice. Functional magnetic resonance imaging (fMRI) among other techniques are often seen as proving the future of neuroimaging. Yet these techniques are much more expensive and are more technically difficult to administer. The authors’ hope is that SPECT does not get left out because of a lack of understanding or training in the use of this valuable tool.