RESEARCH ARTICLE


Extension of Quantifiable Modification of sLORETA for Induced Oscillatory Changes in Magnetoencephalography



Takehiro Uda*, 1, Naohiro Tsuyuguchi 1, Eiichi Okumura 2, Yoshihito Shigihara 3, Takashi Nagata 1, Yuzo Terakawa 1, Shinichi Sakamoto 4, Kenji Ohata 1
1 Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
2 MEG Gr. Bio. & Analytical Center, Yokogawa Electric Corporation, Japan
3 Department of Physiology, Osaka City University Graduate School of Medicine, Japan
4 Department of Radiology, Osaka City University Graduate School of Medicine, Japan


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© Uda et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan; Tel: +81-6-6645-3846; Fax: +81-6-6647-8065; E-mail: uda_takehiro@hotmail.com


Abstract

Quantifiable modification of standardized low-resolution brain electromagnetic tomography (sLORETA-qm), which is one of the non-adaptive beamformer spatial filtering techniques, has been applied to source localization and quantification of evoked field or oscillatory changes in magnetoencephalography (MEG). Here, we extended this technique to induced oscillatory brain activity changes, so-called event-related desynchronization or event-related synchronization. For localizing of significantly activated brain areas at the whole-brain level, permutation tests and multiple comparison corrections with false discovery rate were applied. Induced β- and γ-band oscillatory changes by right hand clenching task were demonstrated as an example of simple induced brain activity.

Keywords: Magnetoencephalography, sLORETA-qm, quantitative analysis, ERD/ERS, oscillatory change, induced activity.