Absolute Oxygenation Metabolism Measurements Using Magnetic Resonance Imaging
Hongyu An*, 1, Qingwei Liu1, Cihat Eldeniz1, Weili Lin1, 2
Identifiers and Pagination:Year: 2011
Issue: Suppl 1
First Page: 120
Last Page: 135
Publisher ID: TONIJ-5-120
Article History:Received Date: 5/11/2011
Revision Received Date: 2/2/2011
Acceptance Date: 3/3/2011
Electronic publication date: 4/11/2011
Collection year: 2011
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Cerebral oxygen metabolism plays a critical role in maintaining normal function of the brain. It is the primary energy source to sustain neuronal functions. Abnormalities in oxygen metabolism occur in various neuro-pathologic conditions such as ischemic stroke, cerebral trauma, cancer, Alzheimer’s disease and shock. Therefore, the ability to quantitatively measure tissue oxygenation and oxygen metabolism is essential to the understanding of pathophysiology and treatment of various diseases. The focus of this review is to provide an introduction of various blood oxygenation level dependent (BOLD) contrast methods for absolute measurements of tissue oxygenation, including both magnitude and phase image based approaches. The advantages and disadvantages of each method are discussed.